bacteria, plague, microscopic view, mega brutal difficulty, petri dish, aggressive spread, high virulence, antibiotic resistance, complex structures, detailed textures, ominous lighting, close-up shot, scientific environment, laboratory setting, biohazard symbol, pandemic scenario, global crisis, enhanced detail, vibrant colors, ominous atmosphere, pathogen evolution, cellular mutation, 3D rendering, high magnification, medical emergency, global map, infection hotspots, red warning signs, strategic gameplay elements, realistic simulation, critical situation, urgent response, world health defense, epidemic control measures.