The Binding of Isaac: Rebirth, indie game, top-down shooter, roguelike, dark fantasy, pixel art style, dungeon crawler, multiple endings, procedurally generated levels, item synergies, challenging gameplay, atmospheric, moody lighting, detailed environments, grotesque monsters, Isaac character, crying attack, power-ups, collectibles, secret rooms, boss fights, co-op mode, expansion packs available, The Binding of Isaac: Afterbirth, The Binding of Isaac: Afterbirth+, The Binding of Isaac: Repentance, enhanced graphics, additional content, improved mechanics, Steam platform, critical acclaim.